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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DEF6/IBP Polyclonal Antibody

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货号 TMAB-05056

Anti-DEF6/IBP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DEF6/IBP。Anti-DEF6/IBP Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-DEF6/IBP Polyclonal Antibody

Anti-DEF6/IBP Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05056

Anti-DEF6/IBP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DEF6/IBP。Anti-DEF6/IBP Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-DEF6/IBP Polyclonal Antibody is a Rabbit antibody targeting DEF6/IBP. Anti-DEF6/IBP Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate.
组织特异性Broadly expressed in the immune system and can be detected in T and B-cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景DEF6 is a 631 amino acid protein that is widely expressed in T and B cells of the immune system. Localized to the nucleus, cytoplasm and cell membrane, DEF6 is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) that functions to activate Rho GTPases such as Rac 1, Cdc42 and Rho A. Via its ability to activate various Rho GTPases, DEF6 can regulate cell shape, movement and polarity and, through its interaction with T helper cells, DEF6 can also help mediate the immune response. DEF6 contains one PH (pleckstrin homology) domain which is required for binding to phosphatidylinositol 3,4,5-trisphosphate and subsequent recruitment to the plasma membrane.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DEF6/IBP
抗原种属
Human
基因名称
DEF6
基因ID
50619
蛋白名称
Differentially expressed in FDCP 6 homolog
Uniprot ID
Q9H4E7
功能
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling.
化学信息
分子量Theoretical: 74 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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