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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DDR2 Polyclonal Antibody

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货号 TMAB-05034

Anti-DDR2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DDR2。Anti-DDR2 Polyclonal Antibody 可用于 WB,ELISA。

Anti-DDR2 Polyclonal Antibody

Anti-DDR2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-05034

Anti-DDR2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DDR2。Anti-DDR2 Polyclonal Antibody 可用于 WB,ELISA。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-DDR2 Polyclonal Antibody is a Rabbit antibody targeting DDR2. Anti-DDR2 Polyclonal Antibody can be used in WB,ELISA.
Ig Type
IgG
反应种属
Human
应用WBELISA
推荐剂量
WB: 1:500-2000; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein.
组织特异性Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage. Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
构建方式Hybridoma Polyclonal Antibody
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
Recombinant Protein: human DDR2 protein
抗原种属
Human
基因名称
DDR2
基因ID
4921
蛋白名称
Discoidin domain-containing receptor 2
Uniprot ID
Q16832
功能
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
化学信息
分子量Theoretical: 92 kDa. Actual: 110-120 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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