购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DcR2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05012

Anti-DcR2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DcR2。Anti-DcR2 Polyclonal Antibody 可用于 WB,FCM。

Anti-DcR2 Polyclonal Antibody

Anti-DcR2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05012

Anti-DcR2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DcR2。Anti-DcR2 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-DcR2 Polyclonal Antibody is a Rabbit antibody targeting DcR2. Anti-DcR2 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane rotein.
组织特异性Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified and designated DcR2. The DcR2 receptor is 386 amino acids in length and has an extracellular TRAIL binding domain, but lacks intracellular death domain and does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 and DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DcR2
抗原种属
Human
基因名称
TNFRSF10D
基因ID
8793
蛋白名称
Tumor necrosis factor receptor superfamily member 10D
Uniprot ID
Q9UBN6
功能
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
化学信息
分子量Theoretical: 36 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-DcR2 Polyclonal Antibody | purchase Anti-DcR2 Polyclonal Antibody | Anti-DcR2 Polyclonal Antibody cost | order Anti-DcR2 Polyclonal Antibody | Anti-DcR2 Polyclonal Antibody molecular weight