Anti-DC-SIGNR1/CD209b Polyclonal Antibody is a Rabbit antibody targeting DC-SIGNR1/CD209b. Anti-DC-SIGNR1/CD209b Polyclonal Antibody can be used in WB.

IgG

Mouse

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: mouse CD209b

Mouse

Cd209b

CD209 antigen-like protein B

SIGN R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. MZM of the spleen are involved in the clearance of polysaccharides. Mouse SIGN R1 is a C type lectin, like DC SIGN which is expressed on Human dendritic cells (DCs). However, Mmouse SIGN R1 itself is not expressed on DCs. SIGN R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides.