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Anti-Cytokeratin 8 Antibody (3S817)
还可以产品编号 TMAY-01277
Anti-Cytokeratin 8 Antibody (3S817) 是一种 Mouse 抗体，靶向 Cytokeratin 8。Anti-Cytokeratin 8 Antibody (3S817) 可用于 IHC-P,ICC/IF。
Anti-Cytokeratin 8 Antibody (3S817)
Anti-Cytokeratin 8 Antibody (3S817)
还可以产品编号 TMAY-01277
Anti-Cytokeratin 8 Antibody (3S817) 是一种 Mouse 抗体，靶向 Cytokeratin 8。Anti-Cytokeratin 8 Antibody (3S817) 可用于 IHC-P,ICC/IF。
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| 产品描述 | Anti-Cytokeratin 8 Antibody (3S817) is a Mouse antibody targeting Cytokeratin 8. Anti-Cytokeratin 8 Antibody (3S817) can be used in IHC-P,ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3S817 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human Cytokeratin 8 in human liver with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human Cytokeratin 8 in human prostate with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human Cytokeratin 8 in human colon carcinoma with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 4. Immunochemical staining of human Cytokeratin 8 in human small intestine with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 5. Immunofluorescence staining of KRT8 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human KRT8 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm. |
| 应用 | IHC-P,ICC/IF |
| 推荐剂量 | IHC-P: 1:500-1:5000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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