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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Cytokeratin 17 Antibody (2S594)

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货号 TMAB-04943

Anti-Cytokeratin 17 Antibody (2S594) 是一种 Rabbit 抗体，靶向 Cytokeratin 17。Anti-Cytokeratin 17 Antibody (2S594) 可用于 IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-Cytokeratin 17 Antibody (2S594)

Anti-Cytokeratin 17 Antibody (2S594)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04943

Anti-Cytokeratin 17 Antibody (2S594) 是一种 Rabbit 抗体，靶向 Cytokeratin 17。Anti-Cytokeratin 17 Antibody (2S594) 可用于 IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-Cytokeratin 17 Antibody (2S594) is a Rabbit antibody targeting Cytokeratin 17. Anti-Cytokeratin 17 Antibody (2S594) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
2S594
反应种属
Human,Mouse,Rat
应用IHC-PIHC-FrICC/IFIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].
抗原信息
免疫原
A synthesized peptide: human Cytokeratin 17
抗原种属
Human
基因名称
KRT17
基因ID
3872
蛋白名称
Keratin, type I cytoskeletal 17
Uniprot ID
Q04695
功能
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repai.
化学信息
分子量Theoretical: 47 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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