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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CYLD Antibody (1O247)

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货号 TMAB-04862

Anti-CYLD Antibody (1O247) 是一种 Mouse 抗体，靶向 CYLD。Anti-CYLD Antibody (1O247) 可用于 WB,ELISA,IHC-P,IHC-Fr,IF。

Anti-CYLD Antibody (1O247)

Anti-CYLD Antibody (1O247)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04862

Anti-CYLD Antibody (1O247) 是一种 Mouse 抗体，靶向 CYLD。Anti-CYLD Antibody (1O247) 可用于 WB,ELISA,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,575
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-CYLD Antibody (1O247) is a Mouse antibody targeting CYLD. Anti-CYLD Antibody (1O247) can be used in WB,ELISA,IHC-P,IHC-Fr,IF.
Ig Type
IgG1
克隆号
1O247
反应种属
Human
应用WBELISAIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; ELISA: 1:1000-5000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase.
组织特异性Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Defects in CYLD are the cause of familial cylindromatosis (CYLD) also known as turban tumor syndrome or dermal eccrine cylindromatosis. CYLD is an autosomal dominant and highly tumor type-specific disorder. The tumors (known as cylindromas because of their characteristic microscopic architecture) are believed to arise from or recapitulate the appearance of the eccrine or apocrine cells of the skin that secrete sweat and scent respectively. Cylindromas arise predominantly in hairy parts of the body with approximately 90% on the head and neck. The development of a confluent mass which may ulcerate or become infected has led to the designation "turban tumor syndrome". The skin tumors show differentiation in the direction of hair structures, hence the synonym trichoepithelioma. CYLD has deubiquitinating activity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CYLD
抗原种属
Human
基因名称
CYLD
基因ID
1540
蛋白名称
Ubiquitin carboxyl-terminal hydrolase CYLD
Uniprot ID
Q9NQC7
功能
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.
化学信息
分子量Theoretical: 105 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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