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Anti-Cyclophilin A Antibody (4R688)
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产品编号 TMAH-00998
别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4R688) 是一种抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4R688) 可用于 ELISA, WB。
Anti-Cyclophilin A Antibody (4R688)
Anti-Cyclophilin A Antibody (4R688)
还可以产品编号 TMAH-00998 别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4R688) 是一种抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4R688) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Cyclophilin A Antibody (4R688) is an antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4R688) can be used in ELISA, WB. |
| 别名 | peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA |
| Ig Type | Rabbit IgG |
| 克隆号 | 4R688 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: Raji whole cell lysate, HepG2 whole cell lysate -All lanes: Cyclophilin A antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 19, 12 kDa -Observed band size: 19 kDa |
| 应用 | |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Secreted. Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans. Inhibits replication of influenza A virus (IAV). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV. (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus. (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Cyclophilin A |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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