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Anti-Cyclin D3 Antibody (4M184)

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货号 TMAB-04832

Anti-Cyclin D3 Antibody (4M184) 是一种 Mouse 抗体，靶向 Cyclin D3。Anti-Cyclin D3 Antibody (4M184) 可用于 WB,ICC/IF。

Anti-Cyclin D3 Antibody (4M184)

Anti-Cyclin D3 Antibody (4M184)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04832

Anti-Cyclin D3 Antibody (4M184) 是一种 Mouse 抗体，靶向 Cyclin D3。Anti-Cyclin D3 Antibody (4M184) 可用于 WB,ICC/IF。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cyclin D3 Antibody (4M184) is a Mouse antibody targeting Cyclin D3. Anti-Cyclin D3 Antibody (4M184) can be used in WB,ICC/IF.
Ig Type
IgG1, Kappa
克隆号
4M184
反应种属
Human,Rat
应用WBICC/IF
推荐剂量
WB: 1:500-1000; ICC/IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
抗原信息
基因名称
CCND3
基因ID
896
蛋白名称
G1/S-specific cyclin-D3
功能
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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