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Anti-CXCR4 Polyclonal Antibody 3

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货号 TMAB-04807

Anti-CXCR4 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 CXCR4。Anti-CXCR4 Polyclonal Antibody 3 可用于 WB,FCM。

Anti-CXCR4 Polyclonal Antibody 3

Anti-CXCR4 Polyclonal Antibody 3

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Rating icon 还可以
货号 TMAB-04807

Anti-CXCR4 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 CXCR4。Anti-CXCR4 Polyclonal Antibody 3 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-CXCR4 Polyclonal Antibody 3 is a Rabbit antibody targeting CXCR4. Anti-CXCR4 Polyclonal Antibody 3 can be used in WB,FCM.
Ig Type
IgG
反应种属
Mouse (predicted:Rat)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
组织特异性Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Monomer. Can form dimers.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse CXCR4
抗原种属
Mouse
基因名称
CXCR4
基因ID
12767
蛋白名称
C-X-C chemokine receptor type 4
Uniprot ID
P70658
功能
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
化学信息
分子量Theoretical: 40 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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