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Anti-Cubilin Antibody (2A269)

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货号 TMAB-04779

Anti-Cubilin Antibody (2A269) 是一种 Rabbit 抗体，靶向 Cubilin。Anti-Cubilin Antibody (2A269) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Cubilin Antibody (2A269)

Anti-Cubilin Antibody (2A269)

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Rating icon 还可以
货号 TMAB-04779

Anti-Cubilin Antibody (2A269) 是一种 Rabbit 抗体，靶向 Cubilin。Anti-Cubilin Antibody (2A269) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cubilin Antibody (2A269) is a Rabbit antibody targeting Cubilin. Anti-Cubilin Antibody (2A269) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
2A269
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
组织特异性Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.
浓度1mg/ml
研究背景Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Cubilin co-localizes with and binds to Megalin, a 600kDa member of the LDL receptor family that is required for the internalization of cubilin-bound ligands, such as vitamin B12, apolipoprotein A1 and Albumin. Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12.
抗原信息
免疫原
Recombinant Protein: human Cubilin protein
抗原种属
Human
基因名称
CUBN
基因ID
8029
蛋白名称
Cubilin
Uniprot ID
O60494
化学信息
分子量Theoretical: 395 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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