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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CTNS Polyclonal Antibody

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货号 TMAB-04765

Anti-CTNS Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CTNS。Anti-CTNS Polyclonal Antibody 可用于 WB。

Anti-CTNS Polyclonal Antibody

Anti-CTNS Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04765

Anti-CTNS Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CTNS。Anti-CTNS Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-CTNS Polyclonal Antibody is a Rabbit antibody targeting CTNS. Anti-CTNS Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Lysosome membrane; Multi-pass membrane protein.
组织特异性Strongly expressed in pancreas, kidney (adult and fetal) and in skeletal muscle. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Cystinosis is an autosomal recessive disorder resulting from defective lysosomal transport of cystine and present at birth as a failure to thrive, rickets and proximal renal tubular acidosis. The human CTNS gene on chromosome 17p13 encodes the protein Cystinosin, and mutations in CTNS are responsible for nephropathic cystinosis. The CTNS promoter contains an Sp1 binding element. Cystinosin is an integral membrane protein containing 7 transmembrane domains that functions as a H+-driven transporter responsible for cystine export from lysosomes. In humans, Cystinosin is expressed abundantly in pancreas, kidney (mature and fetal), and skeletal muscle. The mouse homolog to CTNS encodes a protein which is expressed in all tissues except skeletal muscle. In the cell, Cystinosin co-localizes with LAMP-2 to lysosomes. A C-terminal GYDQL sorting motif within Cystinosin is critical for lysosomal localization.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CTNS/Cystinosin
抗原种属
Human
基因名称
CTNS
基因ID
1497
蛋白名称
Cystinosin
Uniprot ID
O60931
功能
CTNS (Cystinosin) is thought to transport cystine out of lysosomes. Mutations in the CTNS gene are the cause of cystinosis.
化学信息
分子量Theoretical: 42 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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