Anti-CSNK1G2 Polyclonal Antibody 2 is a Rabbit antibody targeting CSNK1G2. Anti-CSNK1G2 Polyclonal Antibody 2 can be used in FCM.

IgG

Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse)

FCM: 2μg/Test

Polyclonal

KLH conjugated synthetic peptide: human CK1g2/Casein Kinase 1 gamma 2

Human

CSNK1G2

Casein kinase I isoform gamma-2

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.