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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Cryptochrome 1 Polyclonal Antibody

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货号 TMAB-04713

Anti-Cryptochrome 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cryptochrome 1。Anti-Cryptochrome 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Cryptochrome 1 Polyclonal Antibody

Anti-Cryptochrome 1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04713

Anti-Cryptochrome 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cryptochrome 1。Anti-Cryptochrome 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-Cryptochrome 1 Polyclonal Antibody is a Rabbit antibody targeting Cryptochrome 1. Anti-Cryptochrome 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Circadian clocks are biological timepieces that regulate hormonal rhythms, sleep cycles and feeding behaviors. These rhythms are generated in the superchiasmatic nucleus (SCN), a cell-autonomous circadian oscillator located within the brain that is synchronized with the environment by light. A number of transcription factors, including Clock and BMAL1, are molecular components of the SCN that induce the expression of proteins involved in light/dark cycle entrainment, which include Per1 and Per2. Tim, for timeless, generates a negative feedback loop that regulates the activity of Clock by suppressing the expression of Clock target genes. Tim forms heterodimers with Per1 and Per2 that bind Clock and block the activation of Clock-BMAL1 dimers to repress Per gene expression. Additionally, the CRY proteins, which are cryptochrome photoreceptors for the circadian clock, function as light-independent inhibitors of the circadian clock. CRY1 and CRY2 negatively regulate SCN components by associating with the activators Clock-BMAL1, and also with the various feedback inhibitors Per1, Per2 and Tim.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Cryptochrome 1
抗原种属
Human
基因名称
CRY1
基因ID
1407
蛋白名称
Cryptochrome-1
Uniprot ID
Q16526
功能
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK
NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK.
化学信息
分子量Theoretical: 64 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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