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Anti-CRTC1 Monoclonal Antibody (8P54)

Synonyms: WAMTP1, TORC1, MECT1, KIAA0616, FLJ14027, CRTC1
货号 TMAT-1394 一键复制产品信息
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Anti-CRTC1 Monoclonal Antibody (8P54) 是一种 Mouse 抗体，靶向 CRTC1。Anti-CRTC1 Monoclonal Antibody (8P54) 可用于 WB,IF,FCM。

Anti-CRTC1 Monoclonal Antibody (8P54)

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Rating icon 还可以
货号 TMAT-1394

别名 WAMTP1, TORC1, MECT1, KIAA0616, FLJ14027, CRTC1

Anti-CRTC1 Monoclonal Antibody (8P54) 是一种 Mouse 抗体，靶向 CRTC1。Anti-CRTC1 Monoclonal Antibody (8P54) 可用于 WB,IF,FCM。

Anti-CRTC1 Monoclonal Antibody (8P54)
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产品介绍

生物活性
产品描述
Anti-CRTC1 Monoclonal Antibody (8P54) is a Mouse antibody targeting CRTC1. Anti-CRTC1 Monoclonal Antibody (8P54) can be used in WB,IF,FCM.
别名
WAMTP1, TORC1, MECT1, KIAA0616, FLJ14027, CRTC1
Ig Type
IgG1
克隆号
8P54
反应种属
Human
应用WBIFFCM
推荐剂量
WB: 1/500-1/2000; IF: 1/200-1/1000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human CRTC1 expressed in E. Coli.
抗原种属
Human
基因名称
CRTC1
基因ID
23373
蛋白名称
CREB-regulated transcription coactivator 1
Uniprot ID
Q6UUV9
化学信息
分子量Theoretical: 67 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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