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Anti-Cripto Antibody (6V546)

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货号 TMAY-01320

别名 teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR

Anti-Cripto Antibody (6V546) 是一种 Mouse 抗体,靶向 Cripto。Anti-Cripto Antibody (6V546) 可用于 ELISA。

Anti-Cripto Antibody (6V546)

Anti-Cripto Antibody (6V546)

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货号 TMAY-01320 别名 teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR

Anti-Cripto Antibody (6V546) 是一种 Mouse 抗体,靶向 Cripto。Anti-Cripto Antibody (6V546) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,684
5日内发货
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产品介绍


生物活性
产品描述
Anti-Cripto Antibody (6V546) is a Mouse antibody targeting Cripto. Anti-Cripto Antibody (6V546) can be used in ELISA.
别名teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR
Ig Type
Mouse IgG1
克隆号
6V546
反应种属
Human
特异性
Human Cripto
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cripto / TDGF1 / CRGF (rh Cripto / TDGF1 / CRGF; TMPY-01413; AAH22393.1; Met1-Thr172). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human Cripto / TDGF1 / CRGF Protein (TMPY-01413)
抗原种属
Human
研究领域
Cardiac Stem Cell Markers
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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