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Anti-Cripto Antibody (6V546)
还可以产品编号 TMAY-01320
Anti-Cripto Antibody (6V546) 是一种 Mouse 抗体，靶向 Cripto。Anti-Cripto Antibody (6V546) 可用于 ELISA。
Anti-Cripto Antibody (6V546)
Anti-Cripto Antibody (6V546)
还可以产品编号 TMAY-01320
Anti-Cripto Antibody (6V546) 是一种 Mouse 抗体，靶向 Cripto。Anti-Cripto Antibody (6V546) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Cripto Antibody (6V546) is a Mouse antibody targeting Cripto. Anti-Cripto Antibody (6V546) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6V546 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cripto / TDGF1 / CRGF (rh Cripto / TDGF1 / CRGF; TMPY-01413; AAH22393.1; Met1-Thr172). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Cripto / TDGF1 / CRGF Protein (TMPY-01413) |
| 抗原种属 | Human |
| 研究领域 | Cardiac Stem Cell Markers |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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