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Anti-CRIP2 Antibody (5S293)
还可以产品编号 TMAY-02739
Anti-CRIP2 Antibody (5S293) 是一种 Mouse 抗体，靶向 CRIP2。Anti-CRIP2 Antibody (5S293) 可用于 IHC-P。
Anti-CRIP2 Antibody (5S293)
Anti-CRIP2 Antibody (5S293)
还可以产品编号 TMAY-02739
Anti-CRIP2 Antibody (5S293) 是一种 Mouse 抗体，靶向 CRIP2。Anti-CRIP2 Antibody (5S293) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CRIP2 Antibody (5S293) is a Mouse antibody targeting CRIP2. Anti-CRIP2 Antibody (5S293) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5S293 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human CRIP2 in human placenta with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRIP2 (rh CRIP2; TMPY-03342; P52943; Met1-Pro208). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CRIP2 protein (TMPY-03342) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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