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Anti-CREB3L3 Polyclonal Antibody 2

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货号 TMAB-04653

Anti-CREB3L3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CREB3L3。Anti-CREB3L3 Polyclonal Antibody 2 可用于 WB。

Anti-CREB3L3 Polyclonal Antibody 2

Anti-CREB3L3 Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-04653

Anti-CREB3L3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CREB3L3。Anti-CREB3L3 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-CREB3L3 Polyclonal Antibody 2 is a Rabbit antibody targeting CREB3L3. Anti-CREB3L3 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus.
组织特异性Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events. Function : Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse CREB3L3
抗原种属
Mouse
基因名称
Creb3l3
基因ID
84699
蛋白名称
Cyclic AMP-responsive element-binding protein 3-like protein 3
功能
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.
化学信息
分子量Theoretical: 49 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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