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Anti-CNOT6 Polyclonal Antibody 2

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货号 TMAB-04491

Anti-CNOT6 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CNOT6。Anti-CNOT6 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-CNOT6 Polyclonal Antibody 2

Anti-CNOT6 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-04491

Anti-CNOT6 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 CNOT6。Anti-CNOT6 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-CNOT6 Polyclonal Antibody 2 is a Rabbit antibody targeting CNOT6. Anti-CNOT6 Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit,Sheep)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic and Nuclear.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景CNOT6 is a widely expressed subunit of the CCR4-NOT transcription complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT6 belongs to the CCR4/nocturin family and contains three LRR (leucine-rich) repeats. In the cytoplasm, CNOT6 acts as a poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the Fos gene.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CNOT6
抗原种属
Human
基因名称
CNOT6
基因ID
57472
蛋白名称
CCR4-NOT transcription complex subunit 6
Uniprot ID
Q9ULM6
功能
Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any.
化学信息
分子量Theoretical: 63 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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