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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CNOT2 Polyclonal Antibody

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货号 TMAB-04490

Anti-CNOT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CNOT2。Anti-CNOT2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-CNOT2 Polyclonal Antibody

Anti-CNOT2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04490

Anti-CNOT2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CNOT2。Anti-CNOT2 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-CNOT2 Polyclonal Antibody is a Rabbit antibody targeting CNOT2. Anti-CNOT2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Pig,Cow,Horse)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
组织特异性Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景CNOT2 (CCR4-NOT transcription complex subunit 2) is a ubiquitous protein encoded by the human gene CNOT2. CNOT2 belongs to the CNOT2/3/5 family and is part of the CCR4-NOT complex. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits (e.g. CNOT1, CNOT2) are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. Increased expression of the CNOT2 subunit acts to strongly repress transcription by RNA polymerase II. This repressive effect is mediated by a conserved NOT-Box, which is located at the C-terminus of CNOT2 proteins. Repression by the NOT-Box is sensitive to treatment with the histone deacetylase (HDAC) inhibitor trichostatin A.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CNOT2
抗原种属
Human
基因名称
CNOT2
基因ID
4848
蛋白名称
CCR4-NOT transcription complex subunit 2
Uniprot ID
Q9NZN8
功能
The CCR4-NOT complex functions as general transcription regulation complex.
化学信息
分子量Theoretical: 59 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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