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Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
还可以产品编号 TMAH-00306
别名 CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide
Anti-CK2 alpha/CSNK2A1 Antibody (2J938) 是一种抗体，靶向 CK2 alpha/CSNK2A1。Anti-CK2 alpha/CSNK2A1 Antibody (2J938) 可用于 ELISA, WB。
Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
还可以产品编号 TMAH-00306 别名 CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide
Anti-CK2 alpha/CSNK2A1 Antibody (2J938) 是一种抗体，靶向 CK2 alpha/CSNK2A1。Anti-CK2 alpha/CSNK2A1 Antibody (2J938) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CK2 alpha/CSNK2A1 Antibody (2J938) is an antibody targeting CK2 alpha/CSNK2A1. Anti-CK2 alpha/CSNK2A1 Antibody (2J938) can be used in ELISA, WB. |
| 别名 | CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide |
| Ig Type | Rabbit IgG |
| 克隆号 | 2J938 |
| 交叉反应 | Human, Mouse |
| 验证活性 | Western Blot -Positive WB detected in: NIH/3T3 whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, U-87 whole cell lysate -All lanes: CKII alpha antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 46, 30 kDa -Observed band size: 45 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human CKII alpha |
| 抗原种属 | Human |
| 基因ID | 1457 |
| Uniprot ID | |
| 研究领域 | Cell biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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