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Anti-CK17 Monoclonal Antibody (8U310) 是一种 Mouse 抗体,靶向 CK17。Anti-CK17 Monoclonal Antibody (8U310) 可用于 WB,IHC。
别名 PCHC1, PC2, PC, KRT17, K17
Anti-CK17 Monoclonal Antibody (8U310) 是一种 Mouse 抗体,靶向 CK17。Anti-CK17 Monoclonal Antibody (8U310) 可用于 WB,IHC。

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| 产品描述 | Anti-CK17 Monoclonal Antibody (8U310) is a Mouse antibody targeting CK17. Anti-CK17 Monoclonal Antibody (8U310) can be used in WB,IHC. |
| 别名 | PCHC1, PC2, PC, KRT17, K17 |
| Ig Type | IgG2b |
| 克隆号 | 8U310 |
| 反应种属 | Human |
| 应用 | WBIHC |
| 推荐剂量 | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Purified by protein A or protein G |
| 性状 | Liquid |
| 缓冲液 | PBS with 0.05% sodium azide. |
| 浓度 | 1 mg/mL |
| 研究背景 | CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. |
| 偶联 | Unconjugated |
| 免疫原 | Purified recombinant fragment of CK17 expressed in E. Coli. |
| 抗原种属 | Human |
| 基因名称 | KRT17 |
| 基因ID | |
| 蛋白名称 | Keratin, type I cytoskeletal 17 |
| Uniprot ID |
| 分子量 | Theoretical: 49 kDa. |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |