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Anti-CK17 Monoclonal Antibody (8U310)

Synonyms: PCHC1, PC2, PC, KRT17, K17
货号 TMAT-1216 一键复制产品信息
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Anti-CK17 Monoclonal Antibody (8U310) 是一种 Mouse 抗体,靶向 CK17。Anti-CK17 Monoclonal Antibody (8U310) 可用于 WB,IHC。

Anti-CK17 Monoclonal Antibody (8U310)

一键复制产品信息
Rating icon 还可以
货号 TMAT-1216

别名 PCHC1, PC2, PC, KRT17, K17

Anti-CK17 Monoclonal Antibody (8U310) 是一种 Mouse 抗体,靶向 CK17。Anti-CK17 Monoclonal Antibody (8U310) 可用于 WB,IHC。

Anti-CK17 Monoclonal Antibody (8U310)
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产品介绍


生物活性
产品描述
Anti-CK17 Monoclonal Antibody (8U310) is a Mouse antibody targeting CK17. Anti-CK17 Monoclonal Antibody (8U310) can be used in WB,IHC.
别名
PCHC1, PC2, PC, KRT17, K17
Ig Type
IgG2b
克隆号
8U310
反应种属
Human
应用WBIHC
推荐剂量
WB: 1/500-1/2000; IHC: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of CK17 expressed in E. Coli.
抗原种属
Human
基因名称
KRT17
基因ID
蛋白名称
Keratin, type I cytoskeletal 17
Uniprot ID
化学信息
分子量Theoretical: 49 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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