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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CIP2A/p90 Autoantigen Polyclonal Antibody

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货号 TMAB-04358

Anti-CIP2A/p90 Autoantigen Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CIP2A/p90 Autoantigen。Anti-CIP2A/p90 Autoantigen Polyclonal Antibody 可用于 ICC/IF,FCM。

Anti-CIP2A/p90 Autoantigen Polyclonal Antibody

Anti-CIP2A/p90 Autoantigen Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04358

Anti-CIP2A/p90 Autoantigen Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CIP2A/p90 Autoantigen。Anti-CIP2A/p90 Autoantigen Polyclonal Antibody 可用于 ICC/IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-CIP2A/p90 Autoantigen Polyclonal Antibody is a Rabbit antibody targeting CIP2A/p90 Autoantigen. Anti-CIP2A/p90 Autoantigen Polyclonal Antibody can be used in ICC/IF,FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Cow,Rabbit)
应用ICC/IFFCM
推荐剂量
ICC/IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region.
组织特异性Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
抗原信息
免疫原
KLH conjugated synthetic peptide: human p90 Autoantigen
抗原种属
Human
基因名称
CIP2A
基因ID
57650
蛋白名称
Protein CIP2A
Uniprot ID
Q8TCG1
化学信息
分子量Theoretical: 100 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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