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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Cingulin Polyclonal Antibody

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货号 TMAB-04357

Anti-Cingulin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cingulin。Anti-Cingulin Polyclonal Antibody 可用于 WB。

Anti-Cingulin Polyclonal Antibody

Anti-Cingulin Polyclonal Antibody

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货号 TMAB-04357

Anti-Cingulin Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cingulin。Anti-Cingulin Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cingulin Polyclonal Antibody is a Rabbit antibody targeting Cingulin. Anti-Cingulin Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.
组织特异性Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Diffusion of solutes is prevented across certain barriers by the formation of tight junction seals. Occludin and Cingulin interact with other proteins to direct the formation and regulation of tight junctions. Cingulin, a protein component of the submembrane plaque of tight junctions (TJ), contains globular and coiled-coil domains and interacts in vitro with several TJ and cytoskeletal proteins, including the PDZ protein ZO-1. Cingulin binding has also been shown to inhibit RhoA activation and signaling with increased Cingulin expression in confluent cells, causing downregulation of RhoA by inhibiting GEF-H1/Lfc.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Cingulin
抗原种属
Human
基因名称
CGN
基因ID
57530
蛋白名称
Cingulin
Uniprot ID
Q9P2M7
功能
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
化学信息
分子量Theoretical: 136 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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