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Anti-CHI3L2 Antibody (6O318)
还可以产品编号 TMAY-02257
Anti-CHI3L2 Antibody (6O318) 是一种 Rabbit 抗体，靶向 CHI3L2。Anti-CHI3L2 Antibody (6O318) 可用于 ELISA,IHC-P。
Anti-CHI3L2 Antibody (6O318)
Anti-CHI3L2 Antibody (6O318)
还可以产品编号 TMAY-02257
Anti-CHI3L2 Antibody (6O318) 是一种 Rabbit 抗体，靶向 CHI3L2。Anti-CHI3L2 Antibody (6O318) 可用于 ELISA,IHC-P。
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偶联与修饰
抗原信息
| 产品描述 | Anti-CHI3L2 Antibody (6O318) is a Rabbit antibody targeting CHI3L2. Anti-CHI3L2 Antibody (6O318) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6O318 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CHI3L2 in human lung with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CHI3L2 in human hepatoma with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human CHI3L2 in human brain with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human YKL-39 / CHI3L2 (rh YKL-39 / CHI3L2; TMPY-01933; NP_003991.2; Met1-Leu390). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in bone and cartilage. A better understanding of the immune response against cartilage-related components including YKL-39 may help to elucidate the pathological processes of arthritic disorders. Upregulation of YKL-39/CHI3L2 in osteoarthritic cartilage suggests that YKL-39/CHI3L2 may be a more accurate marker of chondrocyte activation than YKL-40, although it has yet to be established as a suitable marker in synovial fluid and serum. The decreased expression of YKL-40 by osteoarthritic chondrocytes is surprising as increased levels have been reported in rheumatoid and osteoarthritic synovial fluid, where it may derive from activated synovial cells or osteophytic tissue or by increased matrix destruction in the osteoarthritic joint. YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human YKL-39 / CHI3L2 protein (TMPY-01933) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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