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Anti-CH25H Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CH25H。Anti-CH25H Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。
Anti-CH25H Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CH25H。Anti-CH25H Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,170 | 5日内发货 | |
100 μL | ¥ 1,960 | 5日内发货 | |
200 μL | ¥ 2,780 | 5日内发货 |
产品描述 | Anti-CH25H Polyclonal Antibody is a Rabbit antibody targeting CH25H. Anti-CH25H Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
别名 | h25OH, EC 1.14.99.38, Cholesterol 25 monooxygenase, Cholesterol 25 hydroxylase, CH25H, C25H |
Ig Type | IgG |
交叉反应 | Human |
验证活性 | Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (CH25H) Polyclonal Antibody, Unconjugated (TMAB-00421) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. |
应用 | |
推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
亚细胞定位 | Endoplasmic reticulum membrane |
构建方式 | Hybridoma Polyclonal Antibody |
纯化方式 | Protein A purified |
性状 | Liquid |
缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
研究背景 | CH25H (Cholesterol 25-hydroxylase), also known as h25OH, is a 272 amino acid endoplasmic membrane protein that belongs to the sterol desaturase family. CH25H contains clusters of histidine residues essential for catalytic activity and is involved in cholesterol and lipid metabolism. CH25H catalyzes the formation of 25-hydroxycholesterol from cholesterol leading to the repression of cholesterol biosynthetic enzymes. CH25H regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. CH25H utilizes diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. |
免疫原 | KLH conjugated synthetic peptide: human CH25H |
抗原种属 | Human |
基因ID | |
Uniprot ID | |
研究领域 | Metabolism of lipids and lipoproteins,Cholesterol Metabolism,Oxidative Stress,Cholesterol Metabolism,Lipid metabolism,Oxidative stress |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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