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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Cezanne Polyclonal Antibody

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货号 TMAB-04265

Anti-Cezanne Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cezanne。Anti-Cezanne Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Cezanne Polyclonal Antibody

Anti-Cezanne Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04265

Anti-Cezanne Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cezanne。Anti-Cezanne Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cezanne Polyclonal Antibody is a Rabbit antibody targeting Cezanne. Anti-Cezanne Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
组织特异性Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景OTUD7B (OTU domain-containing protein 7B), also known as ZA20D1 or Cezanne, is an 843 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in a variety of tissues, including liver, kidney, heart and immature B-cells, OTUD7B functions to hydrolyze branched and linear forms of polyubiquitin, specifically deubiquinating Lys-48- and Lys-63-linked polyubiquitin chains. Via its ability to deubiquinate target proteins, OTUD7B regulates the inflammatory response within the cell and may play a role in cell survival. More specifically, OTUD7B forms a negative feedback loop in pro-inflammatory signaling, thereby suppressing NFⅹB activity and helping to resolve inflammatory responses. OTUD7B contains one C-terminal A20-type zinc finger, one OTU domain and one N-terminal TRAF-binding domain through which it conveys its deubiquitinating activity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Cezanne
抗原种属
Human
基因名称
OTUD7B
基因ID
56957
蛋白名称
OTU domain-containing protein 7B
Uniprot ID
Q6GQQ9
功能
Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B.
化学信息
分子量Theoretical: 92 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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