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Anti-Centaurin alpha 1 Polyclonal Antibody

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货号 TMAB-04236

Anti-Centaurin alpha 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Centaurin alpha 1。Anti-Centaurin alpha 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Centaurin alpha 1 Polyclonal Antibody

Anti-Centaurin alpha 1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-04236

Anti-Centaurin alpha 1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Centaurin alpha 1。Anti-Centaurin alpha 1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Centaurin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Centaurin alpha 1. Anti-Centaurin alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cellular localizationCytoplasmic, Nuclear and Plasma membrane
组织特异性Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Centaurin alpha 1
抗原种属
Human
基因名称
ADAP1
基因ID
11033
蛋白名称
Arf-GAP with dual PH domain-containing protein 1
Uniprot ID
O75689
功能
The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
化学信息
分子量Theoretical: 43 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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