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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CENPA Polyclonal Antibody

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货号 TMAB-04223

Anti-CENPA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CENPA。Anti-CENPA Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

Anti-CENPA Polyclonal Antibody

Anti-CENPA Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04223

Anti-CENPA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CENPA。Anti-CENPA Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,ELISA。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

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产品描述
Anti-CENPA Polyclonal Antibody is a Rabbit antibody targeting CENPA. Anti-CENPA Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Ig Type
IgG
反应种属
Human,Mouse
应用IHC-PIHC-FrIFELISA
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.
组织特异性Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB. Poly-ADP-ribosylated by PARP1.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
抗原信息
免疫原
KLH conjugated synthetic peptide: human CENPA
抗原种属
Human
基因名称
CENPA
基因ID
1058
蛋白名称
Histone H3-like centromeric protein A
Uniprot ID
P49450
功能
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
化学信息
分子量Theoretical: 15 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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