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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-CDKN2A/P16 Monoclonal Antibody (2R297)

Synonyms: TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P16, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2, CDK4I, ARF
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Anti-CDKN2A/P16 Monoclonal Antibody (2R297) 是一种 Mouse 抗体，靶向 CDKN2A/P16。Anti-CDKN2A/P16 Monoclonal Antibody (2R297) 可用于 IF,FCM。

Anti-CDKN2A/P16 Monoclonal Antibody (2R297)

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Rating icon 还可以
货号 TMAT-0485

别名 TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P16, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2, CDK4I, ARF

Anti-CDKN2A/P16 Monoclonal Antibody (2R297) 是一种 Mouse 抗体，靶向 CDKN2A/P16。Anti-CDKN2A/P16 Monoclonal Antibody (2R297) 可用于 IF,FCM。

Anti-CDKN2A/P16 Monoclonal Antibody (2R297)
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产品介绍

生物活性
产品描述
Anti-CDKN2A/P16 Monoclonal Antibody (2R297) is a Mouse antibody targeting CDKN2A/P16. Anti-CDKN2A/P16 Monoclonal Antibody (2R297) can be used in IF,FCM.
别名
TP16, P19ARF, P19, P16-INK4A, P16INK4A, P16INK4, P16, P14ARF, P14, MTS-1, MTS1, MLM, INK4A, INK4, CMM2, CDKN2, CDK4I, ARF
Ig Type
IgG1
克隆号
2R297
反应种属
Human
应用IFFCM
推荐剂量
IF: 1/500-1/2000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human CDKN2A/P16 (AA: 1-156) expressed in E. Coli.
抗原种属
Human
基因名称
CDKN2A
基因ID
1029
蛋白名称
Cyclin-dependent kinase inhibitor 2A
Uniprot ID
P42771
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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