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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CDKN2A/p14ARF Polyclonal Antibody

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货号 TMAB-04180

Anti-CDKN2A/p14ARF Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CDKN2A/p14ARF。Anti-CDKN2A/p14ARF Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-CDKN2A/p14ARF Polyclonal Antibody

Anti-CDKN2A/p14ARF Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04180

Anti-CDKN2A/p14ARF Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CDKN2A/p14ARF。Anti-CDKN2A/p14ARF Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-CDKN2A/p14ARF Polyclonal Antibody is a Rabbit antibody targeting CDKN2A/p14ARF. Anti-CDKN2A/p14ARF Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
组织特异性Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
抗原信息
免疫原
KLH conjugated synthetic peptide: human CDKN2A/P14arf
抗原种属
Human
基因名称
Cdkn2a
基因ID
1029
蛋白名称
Tumor suppressor ARF
Uniprot ID
P42771
功能
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
化学信息
分子量Theoretical: 14 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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