购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CDKN1B/p27 KIP 1 Antibody (6O767)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04178

Anti-CDKN1B/p27 KIP 1 Antibody (6O767) 是一种 Mouse 抗体，靶向 CDKN1B/p27 KIP 1。Anti-CDKN1B/p27 KIP 1 Antibody (6O767) 可用于 IHC-P,IHC-Fr,IF。

Anti-CDKN1B/p27 KIP 1 Antibody (6O767)

Anti-CDKN1B/p27 KIP 1 Antibody (6O767)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04178

Anti-CDKN1B/p27 KIP 1 Antibody (6O767) 是一种 Mouse 抗体，靶向 CDKN1B/p27 KIP 1。Anti-CDKN1B/p27 KIP 1 Antibody (6O767) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
200 μg
¥ 5,590
5日内发货
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-CDKN1B/p27 KIP 1 Antibody (6O767) is a Mouse antibody targeting CDKN1B/p27 KIP 1. Anti-CDKN1B/p27 KIP 1 Antibody (6O767) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG1
克隆号
6O767
反应种属
Human
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation.
组织特异性Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
抗原信息
免疫原
Recombinant Protein: human CDKN1B
抗原种属
Human
基因名称
CDKN1B
基因ID
1027
蛋白名称
Cyclin-dependent kinase inhibitor 1B
Uniprot ID
P46527
功能
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
化学信息
分子量Theoretical: 22 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-CDKN1B/p27 KIP 1 Antibody (6O767) | purchase Anti-CDKN1B/p27 KIP 1 Antibody (6O767) | Anti-CDKN1B/p27 KIP 1 Antibody (6O767) cost | order Anti-CDKN1B/p27 KIP 1 Antibody (6O767) | Anti-CDKN1B/p27 KIP 1 Antibody (6O767) molecular weight