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Anti-CDK4 Antibody (2F371)

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货号 TMAB-04163

Anti-CDK4 Antibody (2F371) 是一种 Rabbit 抗体，靶向 CDK4。Anti-CDK4 Antibody (2F371) 可用于 WB,ICC/IF,IP,IHC-P,IHC-Fr,IF,FCM。

Anti-CDK4 Antibody (2F371)

Anti-CDK4 Antibody (2F371)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04163

Anti-CDK4 Antibody (2F371) 是一种 Rabbit 抗体，靶向 CDK4。Anti-CDK4 Antibody (2F371) 可用于 WB,ICC/IF,IP,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

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产品描述
Anti-CDK4 Antibody (2F371) is a Rabbit antibody targeting CDK4. Anti-CDK4 Antibody (2F371) can be used in WB,ICC/IF,IP,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
克隆号
2F371
反应种属
Human,Mouse,Rat
应用WBICC/IFIPIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; IP: 1:20-50; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.
抗原信息
免疫原
A synthesized peptide: human CDK4
抗原种属
Human
基因名称
CDK4
基因ID
1019
蛋白名称
Cyclin-dependent kinase 4 Cyclin-dependent kinase 4
Uniprot ID
P11802
功能
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
化学信息
分子量Theoretical: 34 kDa. Actual: 34 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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