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Anti-CD95/FAS Antibody (2R89)

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货号 TMAB-04102

Anti-CD95/FAS Antibody (2R89) 是一种 Rabbit 抗体，靶向 CD95/FAS。Anti-CD95/FAS Antibody (2R89) 可用于 WB。

Anti-CD95/FAS Antibody (2R89)

Anti-CD95/FAS Antibody (2R89)

一键复制产品信息
Rating icon 还可以
货号 TMAB-04102

Anti-CD95/FAS Antibody (2R89) 是一种 Rabbit 抗体，靶向 CD95/FAS。Anti-CD95/FAS Antibody (2R89) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-CD95/FAS Antibody (2R89) is a Rabbit antibody targeting CD95/FAS. Anti-CD95/FAS Antibody (2R89) can be used in WB.
Ig Type
IgG
克隆号
2R89
反应种属
Human
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.
组织特异性Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
抗原信息
免疫原
Recombinant Protein: protein human CD95/FAS
抗原种属
Human
基因名称
FAS
基因ID
355
蛋白名称
Tumor necrosis factor receptor superfamily member 6
Uniprot ID
P25445
功能
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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