Name: Anti-CD83 Antibody
Brand: TargetMol
SKU: T9901A-1308
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-CD83 Antibody is a humanized monoclonal antibody targeting CD83, a marker for mature dendritic cells (DCs). It interferes with immunomodulatory functions by specifically binding to the extracellular domain of CD83. The antibody works by depleting CD83+ cells or blocking costimulatory signals, serving as an advanced compound tool for studying immune tolerance induction, graft-versus-host disease (GvHD) suppression, and autoimmune disease treatment.
体外活性	在原代人及小鼠树突状细胞培养物中，Anti-CD83 Antibody (3E12) 靶向成熟 DC 并抑制了其刺激 T 细胞反应的能力 [1]。
体内活性	在小鼠胶原诱导的关节炎模型中，通过全身给药方式给予 Anti-CD83 Antibody (3E12)，实验结果显示其显著减轻了关节炎症和骨破坏 [1]。
别名	抗CD83 抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG2SA

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q01151
靶点	CD83

储存&溶解度

存储

Anti-CD83 Antibody