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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-CD80 Monoclonal Antibody (4T630)

Synonyms: LAB7, CD28LG, B7.1
货号 TMAT-0448 一键复制产品信息
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Anti-CD80 Monoclonal Antibody (4T630) 是一种 Mouse 抗体，靶向 CD80。Anti-CD80 Monoclonal Antibody (4T630) 可用于 IHC,IF。

Anti-CD80 Monoclonal Antibody (4T630)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0448

别名 LAB7, CD28LG, B7.1

Anti-CD80 Monoclonal Antibody (4T630) 是一种 Mouse 抗体，靶向 CD80。Anti-CD80 Monoclonal Antibody (4T630) 可用于 IHC,IF。

Anti-CD80 Monoclonal Antibody (4T630)
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产品介绍

生物活性
产品描述
Anti-CD80 Monoclonal Antibody (4T630) is a Mouse antibody targeting CD80. Anti-CD80 Monoclonal Antibody (4T630) can be used in IHC,IF.
别名
LAB7, CD28LG, B7.1
Ig Type
IgG1
克隆号
4T630
反应种属
Human
应用IHCIF
推荐剂量
IHC: 1/200-1/1000; IF: 1/200-1/1000
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of CD80 expressed in E. Coli.
抗原种属
Human
基因名称
CD80
基因ID
941
蛋白名称
T-lymphocyte activation antigen CD80
Uniprot ID
P33681
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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