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Anti-CD6 Antibody-PE (3M203)
还可以产品编号 TMAY-03813P
Anti-CD6 Antibody-PE (3M203) 是一种 PE-conjugated Mouse 抗体，靶向 CD6。Anti-CD6 Antibody-PE (3M203) 可用于 FCM。
Anti-CD6 Antibody-PE (3M203)
Anti-CD6 Antibody-PE (3M203)
还可以产品编号 TMAY-03813P
Anti-CD6 Antibody-PE (3M203) 是一种 PE-conjugated Mouse 抗体，靶向 CD6。Anti-CD6 Antibody-PE (3M203) 可用于 FCM。
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| 产品描述 | Anti-CD6 Antibody-PE (3M203) is a PE-conjugated Mouse antibody targeting CD6. Anti-CD6 Antibody-PE (3M203) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 3M203 |
| 交叉反应 | Rat |
| 验证活性 | Flow cytometric analysis of Rat CD6 expression on SD rat splenocytes. Cells were stained with PE-conjugated anti-Rat CD6. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD6 / Cluster of Differentiation 6 (rR CD6 / Cluster of Differentiation 6; TMPY-03731; Q812A4; Met1-Asn396) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse. |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Rat CD6 / Cluster of Differentiation 6 protein (TMPY-03731) |
| 抗原种属 | Rat |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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