Anti-CD6 Antibody (3M203)

Name: Anti-CD6 Antibody (3M203)
Brand: TargetMol
SKU: TMAY-03813
Rating: 4.5 (1 reviews)

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产品编号 TMAY-03813

Anti-CD6 Antibody (3M203) 是一种 Mouse 抗体，靶向 CD6。Anti-CD6 Antibody (3M203) 可用于 FCM。

Anti-CD6 Antibody (3M203)

还可以

产品编号 TMAY-03813

Anti-CD6 Antibody (3M203) 是一种 Mouse 抗体，靶向 CD6。Anti-CD6 Antibody (3M203) 可用于 FCM。

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生物活性

产品描述	Anti-CD6 Antibody (3M203) is a Mouse antibody targeting CD6. Anti-CD6 Antibody (3M203) can be used in FCM.
Ig Type	Monoclonal Mouse IgG2a
克隆号	3M203
交叉反应	Rat
验证活性	Flow cytometric analysis of Rat CD6 expression on SD rat splenocytes. Cells were stained with purified anti-Rat CD6, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用	FCM
推荐剂量	FCM: 1:25-1:100
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD6 / Cluster of Differentiation 6 (rR CD6 / Cluster of Differentiation 6; TMPY-03731; Q812A4; Met1-Asn396). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

偶联与修饰

偶联	Unconjugated
其他可选修饰符	APC/FITC/PE
可提供抗体种类	4

抗原信息

免疫原	Recombinant Rat CD6 / Cluster of Differentiation 6 Protein (TMPY-03731)
抗原种属	Rat
研究领域	ITIM/ITAM Immunoreceptors and Related Molecules

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.