Anti-CD3D Antibody (2U54)

Name: Anti-CD3D Antibody (2U54)
Brand: TargetMol
SKU: TMAH-00194
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00194

Anti-CD3D Antibody (2U54) 是一种抗体，靶向 CD3D。Anti-CD3D Antibody (2U54) 可用于 ELISA, WB。

Anti-CD3D Antibody (2U54)

还可以

产品编号 TMAH-00194

Anti-CD3D Antibody (2U54) 是一种抗体，靶向 CD3D。Anti-CD3D Antibody (2U54) 可用于 ELISA, WB。

规格	价格	库存	数量
50 μL	¥ 1,315	5日内发货
100 μL	¥ 2,185	5日内发货

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产品描述	Anti-CD3D Antibody (2U54) is an antibody targeting CD3D. Anti-CD3D Antibody (2U54) can be used in ELISA, WB.
Ig Type	hIgG1
克隆号	2U54
交叉反应	Human
验证活性	Western Blot -Positive WB detected in: Jurkat whole cell lysate -All lanes: CD3D antibody at 1:1000 -Secondary: Goat polyclonal to human IgG at 1/50000 dilution -Predicted band size: 19 kDa -Observed band size: 19 kDa
应用	ELISA WB
推荐剂量	WB:1:500-1:2000.
抗体种类	Monoclonal
亚细胞定位	Cell membrane; Single-pass type I membrane protein.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).