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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-CD319 Monoclonal Antibody (6W566)

Synonyms: SLAMF7, CS1, CRACC, 19A
货号 TMAT-0373 一键复制产品信息
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Anti-CD319 Monoclonal Antibody (6W566) 是一种 Mouse 抗体，靶向 CD319。Anti-CD319 Monoclonal Antibody (6W566) 可用于 WB,IHC,FCM。

Anti-CD319 Monoclonal Antibody (6W566)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0373

别名 SLAMF7, CS1, CRACC, 19A

Anti-CD319 Monoclonal Antibody (6W566) 是一种 Mouse 抗体，靶向 CD319。Anti-CD319 Monoclonal Antibody (6W566) 可用于 WB,IHC,FCM。

Anti-CD319 Monoclonal Antibody (6W566)
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产品介绍

生物活性
产品描述
Anti-CD319 Monoclonal Antibody (6W566) is a Mouse antibody targeting CD319. Anti-CD319 Monoclonal Antibody (6W566) can be used in WB,IHC,FCM.
别名
SLAMF7, CS1, CRACC, 19A
Ig Type
IgG1
克隆号
6W566
反应种属
Human,Mouse,Rat,Monkey,Rabbit
应用WBIHCFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human CD319 (AA: extra(23-226)) expressed in E. Coli.
抗原种属
Human
基因名称
SLAMF7
基因ID
57823
蛋白名称
SLAM family member 7
Uniprot ID
Q9NQ25
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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