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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CD31 Antibody (4D341)

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货号 TMAB-03944

Anti-CD31 Antibody (4D341) 是一种 Rabbit 抗体，靶向 CD31。Anti-CD31 Antibody (4D341) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

Anti-CD31 Antibody (4D341)

Anti-CD31 Antibody (4D341)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03944

Anti-CD31 Antibody (4D341) 是一种 Rabbit 抗体，靶向 CD31。Anti-CD31 Antibody (4D341) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-CD31 Antibody (4D341) is a Rabbit antibody targeting CD31. Anti-CD31 Antibody (4D341) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM.
Ig Type
IgG
克隆号
4D341
反应种属
Human
应用WBIHC-PIHC-FrIFICC/IFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:200-500; IHC-Fr: 1:200-500; IF: 1:200-500; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
组织特异性Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369).Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308).Expressed on neutrophils (at protein level) (PubMed:17580308).Isoform Long predominates in all tissues examined (PubMed:12433657).Isoform Delta12 is detected only in trachea (PubMed:12433657).Isoform Delta14-15 is only detected in lung (PubMed:12433657).Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657).Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
抗原信息
免疫原
A synthesized peptide: human PECAM 1
抗原种属
Human
基因名称
PECAM1
基因ID
5175
蛋白名称
Platelet endothelial cell adhesion molecule
Uniprot ID
P16284
功能
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).Induces susceptibility to atherosclerosis (By similarity).
化学信息
分子量Theoretical: 82 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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