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Anti-CD25/IL2R alpha Antibody-PerCP (5R661)
还可以产品编号 TMAY-00386C
Anti-CD25/IL2R alpha Antibody-PerCP (5R661) 是一种 PerCP-conjugated Rabbit 抗体，靶向 CD25/IL2R alpha。Anti-CD25/IL2R alpha Antibody-PerCP (5R661) 可用于 FCM。
Anti-CD25/IL2R alpha Antibody-PerCP (5R661)
Anti-CD25/IL2R alpha Antibody-PerCP (5R661)
还可以产品编号 TMAY-00386C
Anti-CD25/IL2R alpha Antibody-PerCP (5R661) 是一种 PerCP-conjugated Rabbit 抗体，靶向 CD25/IL2R alpha。Anti-CD25/IL2R alpha Antibody-PerCP (5R661) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD25/IL2R alpha Antibody-PerCP (5R661) is a PerCP-conjugated Rabbit antibody targeting CD25/IL2R alpha. Anti-CD25/IL2R alpha Antibody-PerCP (5R661) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5R661 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of IL2RA(CD25) expression on stimulated human peripheral blood lymphocytes. Human peripheral blood mononuclear cells were stimulated for 3 days with Phytohemagglutinin, then stained with PerCP-conjugated anti-Human IL2RA(CD25). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL2RA/IL-2RA/CD25 (rh IL2RA/IL-2RA/CD25; TMPY-01103; NP_000408.1; Met1-Cys213) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | CD25 (alpha-chain of the IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high-affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates the intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a piece of strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development are associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of SIL-2Ralpha. In most hematological malignancies, including different types of leukemias and lymphomas, SIL-2Ralpha is released directly from the surface of neoplastic cells thus reflecting the tumor bulk, turnover, and activity. Several studies have proved that not only lymphoid cancer cells but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, esophagus, and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and many solid tumors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PerCP |
| 其他可选修饰符 | Unconjugated/APC/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human IL2RA/IL-2RA/CD25 Protein (TMPY-01103) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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