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Anti-CD204/MSR1 Polyclonal Antibody

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货号 TMAB-00345

别名 SR-A, SRA, SCARA1, phSR2, phSR1, macrophage scavenger receptor 1, CD204

Anti-CD204/MSR1 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CD204/MSR1。Anti-CD204/MSR1 Polyclonal Antibody 可用于 WB。

Anti-CD204/MSR1 Polyclonal Antibody

Anti-CD204/MSR1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-00345 别名 SR-A, SRA, SCARA1, phSR2, phSR1, macrophage scavenger receptor 1, CD204

Anti-CD204/MSR1 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 CD204/MSR1。Anti-CD204/MSR1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍


生物活性
产品描述
Anti-CD204/MSR1 Polyclonal Antibody is a Rabbit antibody targeting CD204/MSR1. Anti-CD204/MSR1 Polyclonal Antibody can be used in WB.
别名SR-A, SRA, SCARA1, phSR2, phSR1, macrophage scavenger receptor 1, CD204
Ig Type
IgG
反应种属
Mouse,Rat
验证活性
Sample:
Lane 1: Spleen (Mouse) Lysate at 40 μg
Lane 2: Lung (Mouse) Lysate at 40 μg
Lane 3: Liver (Mouse) Lysate at 40 μg
Lane 4: Placenta (Mouse) Lysate at 40 μg
Lane 5: Cerebrum (Mouse) Lysate at 40 μg
Lane 6: Raw264.7 (Mouse) Cell Lysate at 30 μg
Lane 7: NIH/3T3 (Mouse) Cell Lysate at 30 μg
Lane 8: Liver (Rat) Lysate at 40 μg
Lane 9: Cerebrum (Rat) Lysate at 40 μg
Primary: Anti-MSR1 (TMAB-00345) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50/39 kDa
Observed band size: 50 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type II membrane protein.
组织特异性Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human MSR1/CD204
抗原种属
Human
基因名称
MSR1
基因ID
蛋白名称
Macrophage scavenger receptor types I and II
Uniprot ID
研究领域
Heart disease,Lipoprotein metabolism,Macrophage / Inflamm.,Innate and adaptive immunity,Lipoprotein metabolism
功能
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.
化学信息
分子量Theoretical: 50 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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