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Anti-CD16a Antibody-PE (5Q617)

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产品编号 TMAY-00743P
别名 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Anti-CD16a Antibody-PE (5Q617) 是一种 PE-conjugated Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody-PE (5Q617) 可用于 FCM。

Anti-CD16a Antibody-PE (5Q617)

Anti-CD16a Antibody-PE (5Q617)

Rating icon 还可以
产品编号 TMAY-00743P 别名 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Anti-CD16a Antibody-PE (5Q617) 是一种 PE-conjugated Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody-PE (5Q617) 可用于 FCM。

规格价格库存数量
25 T
¥ 1,085
5日内发货
100 T
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD16a Antibody-PE (5Q617) is a PE-conjugated Mouse antibody targeting CD16a. Anti-CD16a Antibody-PE (5Q617) can be used in FCM.
别名Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Ig Type
Mouse IgG1
克隆号
5Q617
交叉反应
Human
特异性
Human CD16a/FCGR3A/Fc gamma RIIIA
验证活性
Flow cytometric analysis of Human CD16 expression on human whole blood lymphocyte. Cells were stained with PE-conjugated anti-Human CD16. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
应用FCM
推荐剂量
5 μl/Test, 0.1 mg/ml
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a (rh CD16a; TMPY-02816; P08637-1; Met1-Gln208,176F) and conjugated with PE under optimum conditions, the unreacted PE was removed.
纯化方式Protein A
性状Liquid
缓冲液PBS solution containing 0.5% BSA and 0.03%ProClin300
研究背景The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
偶联与修饰
偶联
PE
其他可选修饰符
Unconjugated/APC/PerCP/FITC
可提供抗体种类
5
抗原信息
免疫原
Recombinant Protein: Human CD16a Protein (TMPY-02816)
抗原种属
Human
研究领域
Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
运输方式Shipping with blue ice.

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关键词

Fc fragment of IgG, low affinity IIIa, receptorCD16a

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