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Anti-CD16a Antibody-APC (5Q617)
还可以产品编号 TMAY-00743A
Anti-CD16a Antibody-APC (5Q617) 是一种 APC-conjugated Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody-APC (5Q617) 可用于 FCM。
Anti-CD16a Antibody-APC (5Q617)
Anti-CD16a Antibody-APC (5Q617)
还可以产品编号 TMAY-00743A
Anti-CD16a Antibody-APC (5Q617) 是一种 APC-conjugated Mouse 抗体，靶向 CD16a。Anti-CD16a Antibody-APC (5Q617) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CD16a Antibody-APC (5Q617) is a APC-conjugated Mouse antibody targeting CD16a. Anti-CD16a Antibody-APC (5Q617) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5Q617 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD16 expression on human whole blood lymphocyte. Cells were stained with APC-conjugated anti-Human CD16. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a/FCGR3A (rh CD16a/FCGR3A; TMPY-02816; P08637-1; Met1-Gln208,176F) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human CD16a/FCGR3A Protein (TMPY-02816) |
| 抗原种属 | Human |
| 研究领域 | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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