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Anti-CD163 Antibody (2R634)
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产品编号 TMAH-00173
别名 sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163
Anti-CD163 Antibody (2R634) 是一种抗体，靶向 CD163。Anti-CD163 Antibody (2R634) 可用于 ELISA, IHC。
Anti-CD163 Antibody (2R634)
Anti-CD163 Antibody (2R634)
还可以产品编号 TMAH-00173 别名 sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163
Anti-CD163 Antibody (2R634) 是一种抗体，靶向 CD163。Anti-CD163 Antibody (2R634) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD163 Antibody (2R634) is an antibody targeting CD163. Anti-CD163 Antibody (2R634) can be used in ELISA, IHC. |
| 别名 | sCD163, SCARI1, RM3/1, MM130, M130, HbSR, GHI/61, CD163 molecule, CD163 |
| Ig Type | hIgG1 |
| 克隆号 | 2R634 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00173 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| 应用 | |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. |
| 组织特异性 | Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed a |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CD163 Protein |
| 抗原种属 | Human |
| 基因名称 | CD163 |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Cardiovascular, Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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