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Anti-CBARA1/MICU1 Antibody (4K284)

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货号 TMAB-03708

Anti-CBARA1/MICU1 Antibody (4K284) 是一种 Mouse 抗体，靶向 CBARA1/MICU1。Anti-CBARA1/MICU1 Antibody (4K284) 可用于 WB。

Anti-CBARA1/MICU1 Antibody (4K284)

Anti-CBARA1/MICU1 Antibody (4K284)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03708

Anti-CBARA1/MICU1 Antibody (4K284) 是一种 Mouse 抗体，靶向 CBARA1/MICU1。Anti-CBARA1/MICU1 Antibody (4K284) 可用于 WB。

规格价格库存数量
200 μg
¥ 5,585
5日内发货
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-CBARA1/MICU1 Antibody (4K284) is a Mouse antibody targeting CBARA1/MICU1. Anti-CBARA1/MICU1 Antibody (4K284) can be used in WB.
Ig Type
IgG
克隆号
4K284
反应种属
Human (predicted:Mouse,Rat)
应用WB
推荐剂量
WB: 1:500-1000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space
组织特异性Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
抗原信息
免疫原
Recombinant Protein: human CBARA1 Protein (1-250/476)
抗原种属
Human
基因名称
MICU1
基因ID
10367
蛋白名称
Calcium uptake protein 1, mitochondrial
Uniprot ID
Q9BPX6
功能
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).
化学信息
分子量Theoretical: 54 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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