Anti-Cathepsin L Polyclonal Antibody 2 is a Rabbit antibody targeting Cathepsin L. Anti-Cathepsin L Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.

IgG

Human,Rat (predicted:Mouse)

WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test

Polyclonal

KLH conjugated synthetic peptide: human cathepsin L1 proprotein

Human

CTSL

Procathepsin L

Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676).In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695).In thymus, regulates CD4+ T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells (PubMed:12021314).Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed:9545226).Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed:12417635).Secreted form generates endostatin from COL18A1 (PubMed:10716919).Critical for cardiac morphology and function (PubMed:11972068).Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed:12163394).Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).