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Anti-Cathepsin B Antibody (3H512)
还可以产品编号 TMAY-03085
Anti-Cathepsin B Antibody (3H512) 是一种 Rabbit 抗体，靶向 Cathepsin B。Anti-Cathepsin B Antibody (3H512) 可用于 IHC-P。
Anti-Cathepsin B Antibody (3H512)
Anti-Cathepsin B Antibody (3H512)
还可以产品编号 TMAY-03085
Anti-Cathepsin B Antibody (3H512) 是一种 Rabbit 抗体，靶向 Cathepsin B。Anti-Cathepsin B Antibody (3H512) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-Cathepsin B Antibody (3H512) is a Rabbit antibody targeting Cathepsin B. Anti-Cathepsin B Antibody (3H512) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3H512 |
| 交叉反应 | Mouse |
| 验证活性 | 1. Immunochemical staining of mouse CTSB in mouse liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of mouse CTSB in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Cathepsin B / CTSB (rM Cathepsin B / CTSB; TMPY-02144; P10605; Met1-Phe339). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This protease has been implicated in pathological conditions, e.g., tumor progression and arthritis. In disease conditions, increases in the expression of cathepsin B occur at both the gene and protein levels. Cathepsin B is synthesized as a preproenzyme and the primary pathways for its normal trafficking to the lysosome utilize mannose 6-phosphate receptors (MPRs). Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Cathepsin B expression is increased in many human cancers at the mRNA, protein and activity levels. It is also frequently overexpressed in premalignant lesions, an observation that associates this protease with local invasive stages of cancer. Increased expression of cathepsin B in primary cancers, and especially in preneoplastic lesions, suggests that this enzyme might have pro-apoptotic features. Active cathepsin B is also secreted from tumours, a mechanism likely to be facilitated by lysosomal exocytosis or extracellular processing by surface activators. Cathepsin B is localized to caveolae on the tumour surface, where binding to the annexin II heterotetramer occurs. Thus CTSB is suggested as a tumor marker. Additionally, Cathepsin B can degrade extracellular matrix proteins, such as collagen IV and laminin, and can activate the precursor form of urokinase plasminogen activator (uPA), perhaps thereby initiating an extracellular proteolytic cascade. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse Cathepsin B / CTSB Protein (TMPY-02144) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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