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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CASPR Polyclonal Antibody

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货号 TMAB-03676

Anti-CASPR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CASPR。Anti-CASPR Polyclonal Antibody 可用于 ICC/IF,FCM。

Anti-CASPR Polyclonal Antibody

Anti-CASPR Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03676

Anti-CASPR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CASPR。Anti-CASPR Polyclonal Antibody 可用于 ICC/IF,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-CASPR Polyclonal Antibody is a Rabbit antibody targeting CASPR. Anti-CASPR Polyclonal Antibody can be used in ICC/IF,FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse)
应用ICC/IFFCM
推荐剂量
ICC/IF: 1:100-500; FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane.
组织特异性Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and CASPR (neurexin IV). Neurexins I-III are expressed as å and ∫ isoforms. The å isoforms are made of three cassettes, which contain two LNS (laminin A, neurexins, sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The å isoforms bind to neurexophilins at the second LNS site, and to the excitatory neurotoxin å-latrotoxin. The ∫ isoforms have only one LNS-domain, bind to neuroligins and play a role in the formation and remodeling of synapses. CASPR (for contactin-associated protein 1, also designated paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein contactin. CASPR and the closely related CASPR2, a mammalian homolog of Drosophila neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, CASPR exists at the paranodal junctions, while CASPR2 co-localizes with Shaker-like K+ channels in the juxtaparanodal region. CASPR may play a role in the communication of glial cells and neurons during development.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CASPR/Neurexin4
抗原种属
Human
基因名称
CNTNAP1
基因ID
8506
蛋白名称
Contactin-associated protein 1
Uniprot ID
P78357
功能
Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
化学信息
分子量Theoretical: 154 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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